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New Non-Adictive Opioid-Bu08028


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So the DEA comes out and is going to eliminate Kratom, which has what sounds like the same properties of this new compound, BU08028. I wonder what this new compound is a synthesis of?

 

Full article:
http://arstechnica.com/science/2016/09/new-opioid-douses-pain-without-being-addictive-or-deadly-in-primates/?comments=1
 

While the opioid epidemic continues kill more than 40 Americans every day, researchers
and health experts are frantically searching for ways to curtail use of the highly
addictive, pain-quenching drugs. In March, the Centers for Disease Control and
Prevention even released new guidelines directing doctors to simply refrain from
prescribing opioids. But if a new study holds up, the health agency may be able to
reverse course.

According to a report in the Proceedings of the National Academy of Sciences, an
opioid drug referred to as BU08028 was able to alleviate pain in a dozen monkeys just
as well as other opioid painkillers, such as morphine. Yet, unlike every other opioid
drug, BU08028 showed no signs of being addictive. Even at high dose—at which other
opioid drugs inhibit the respiratory and cardiovascular system, which can be
fatal—BU08028 was harmless.

"Based on our research, this compound has almost zero abuse potential and provides
safe and effective pain relief," Mei-Chuan Ko, a professor of physiology and
pharmacology at Wake Forest Baptist Medical Center and lead author of the study, said
in a statement. "This is a breakthrough for opioid medicinal chemistry that we hope
in the future will translate into new and safer, non-addictive pain medications."

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